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It's also important to note that certain medications and supplements can interact with Synthroid and Levothyroxine, which may affect their effectiveness or cause side effects. When it comes to hypothyroidism treatment, two of the most commonly prescribed medications are Synthroid and Levothyroxine. Overall, while both Synthroid and Levothyroxine are safe and effective for hypothyroidism treatment, some evidence suggests that Synthroid may be better tolerated and more consistent in its effects. ...